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Gut Instinct: How AI and the human microbiome team up against neurodegenerative disorders
By Gaurav Chandra  |  Dec 11, 2023
Gut Instinct: How AI and the human microbiome team up against neurodegenerative disorders
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Neurological diseases like Alzheimer’s and other forms of dementia afflict over 55 million people worldwide. Continuous efforts and advancements in the human microbiome promise to help, aided by AI, though the key may very well be ‘going with one’s gut,’ argues Dr Gaurav Chandra.

DENVER, COLORADO - Debilitating illnesses such as ulcerative colitis, cardiovascular disease, Alzheimer's disease (AD), and autism spectrum disorders cause much suffering and are difficult to treat yet are only partially understood. Artificial intelligence (AI) and machine learning (ML) have revolutionized the pace of scientific discoveries, and the treatment of diseases is no exception. To take the next step, the best approach involves ‘going with one’s gut,’ which leaves plenty of food for thought.

“Science and technology revolutionize our lives, but memory, tradition, and myth frame our response.”

- Arthur M. Schlesinger, US historian and intellectual

Have you ever misplaced your car keys or forgotten the password to your computer for the umpteenth time? How did you feel in that moment? Frustrated? Angry? Overwhelmed? Now, ask yourself how many of us can imagine the fear, loss of dignity, identity, and sense of self that comes with the progression of a neurodegenerative disorder like AD. Our sense of self allows us to position ourselves in the world; it is the essential ingredient that makes us human. Some 55 million people worldwide are believed to be living with AD or other dementias, a number that will almost double every 20 years.1

The human microbiome (HMB) is often referred to as the ‘forgotten organ’ despite its critical role in many physiological processes - it holds the key to understanding and therefore treating many of the aforementioned illnesses. Metabolites produced by the microorganisms in the microbiota are believed to be the primary factor behind these diseases developing in the first place. This discovery opens the door to new biomarkers and less invasive diagnostic procedures, and will potentially prevent the onset of numerou

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